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人类疾病表观遗传学实验室

Lab members
 
PI: Man Mohan  (man@shsmu.edu.cn)
Technician: 付寅坤 (yinkunfu@shsmu.edu.cn)
 
Research interests
Mis-regulation of gene expression is one of the main players in disease development. The objective of our laboratory is to investigate how mis-regulation of chromatin-associated processes lead to disease development especially tumorigenesis. Currently we are focusing our studies onepigenetics marks such histone methylation and how these marks are altered during tumorigenesis. With our investigations, we expect to contribute to field of tumorigenesis, and broadly, to human diseases.
We use a combination of technologies including biochemical, genetic, high-throughput sequencing, and proteomic tools to elucidate the molecular mechanisms of gene transcription and regulation during disease development. We also collaborate with laboratory using state-of-the-art mass spectrometry, and computational methods based on the next-generation sequencing.
 
Lab Grants
1.项目编号:无
项目名称:无
资助类别:上海高校特聘教授 (东方学者) 岗位计划资助
起止年限:2015年1月至2018年1月
资助金额:100万元
2. .项目编号:31471206
项目名称:DOT1介导的H3K79甲基化修饰的调节机制
资助类别:国家自然科学基金,面上项目
起止年限:2015年1月至2018年12月
资助金额:90万元
3. .项目编号:14JC1404000
项目名称:DOT1介导的H3K79甲基化修饰的调节机制
资助类别:上海市科委基础科研项目
起止年限:2014年9月至2017年8月
资助金额:50万元
 
4. 项目编号:无
项目名称:海外人才引进项目
资助类别:上海交通大学医学院
起止年限:2013年1月至2015年12月
资助金额: 200万
 
Significant Publications
1.Mohan M, Herz HM, Shilatifard A. “SnapShot: Histone Lysine Methylase Complexes” Cell. 2012 149, April 13.
2.Herz HM, Mohan M, Garruss AS, Liang K, Takahashi YH, Mickey K, Voets O, Verrijzer CP, Shilatifard A. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.Genes Dev 2012 Dec 1;26(23):2604-20
3.Mohan M, Herz HM, Smith ER, Zhang Y, Jackson J, Washburn MP, Florens L, Eissenberg JC, Shilatifard A. “The COMPASS family of H3K4 methylases in Drosophila.” Mol Cell Biol. 2011 Nov;31(21):4310-8. 
4.Mohan M, Lin C, Guest E, Shilatifard A. “Licensed to elongate: a molecular mechanism for MLL-based leukemogenesis.” Nat Rev Cancer. 2010 Oct;10(10):721-8.
5.Mohan M, Herz HM, Takahashi YH, Lin C, Lai KC, Zhang Y, Washburn MP, Florens L, Shilatifard A.  “Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)” Genes & Dev 2010 Mar 15;24(6):574-89
6.Mohan M, Bartkuhn M, Herold M, Philippen A, Heinl N, Bardenhagen I, Leers J, White RA, Renkawitz-Pohl R, Saumweber H, Renkawitz R. “The Drosophila insulator proteins CTCF and Cp190 link enhancer blocking to body patterning” EMBO J. 2007 Oct 3;26( 19):4203-14
 
We are interested in hiring post-doctoral fellows. Competitive applicants having a background in biochemistry, molecular biology or genetics are encouraged to apply.

 

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